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As described earlier, caspase-4, -5 and -11 cleave GSDMD to induce pyroptosis but are incapable of efficiently processing pro-IL-1 and pro-IL-18, which are processed by caspase-1

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Therefore, to evade CNS off-target effects, it is desirable to develop SMI with elevated lipophilicity to prevent the inhibitor from entering into the brain

Therefore, the key mechanism targets for intervening in liver fibrosis mainly include inhibiting adverse stress, thus negatively regulating inflammatory responses, HSC activation, and ECM deposition (172)

Massage therapy Various massages or relaxation techniques have been found to relieve muscle cramps, tension, and stress caused by diseases among patients